Getting cleaning and disinfection right: Application techniques

BY DR TIM SANDLE  |  12 DECEMBER 2022

Sections 4.33 to 4.36 of the 2022 edition of EU GMP Annex 1 focus on cleaning and disinfection. In this GMP blog, we look at cleaning and disinfection techniques.

For effective cleaning, the application technique is important. Wiping strategy includes the applied pressure force, wiped surface area, the geometry of the mechanical action, the number of passages. Each of these is influenced by the presentation.

There are five primary means of application:

Spray, with no wiping

• This method is the least effective. the absence of mechanical action means there is no physical activity to disassociate organisms from the surface and no direct application and hence penetration of the cleaning agent towards the soil. This method is best avoided.