RSSL invests in Cell Based Assay service expansion

 

The Biomolecular Team's recent expansion into purpose built, state of the art laboratories has given RSSL's Cell Based Assay Service a massive boost - which they are now looking to pass on to clients.

 

Cell based assays encompass a diverse group of analytical testing methods that enable the investigation of how a therapy may function in the recipient and the mechanisms that underpin drug interactions. They are, however, characteristically challenging to develop, due to the complex and inherently variable nature of the assays.  

 

RSSL initially added bioassay testing service to its portfolio in 2019 and has supported many clients with the successful development and validation of cell-based assays including Bispecific T cell engager assays and Custom TCR T cell activation assays. 

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With the recent expansion into the Knight Building, RSSL’s Biomolecular Analytical Team has been relocated into purpose built, state of the art laboratories. These new facilities include a cell culture suite with dedicated and lobbied laboratories, providing segregated workflows and increased contamination control, providing a high standard of safety assurance. 

 

The Knight Building is also equipped with a containment laboratory, supporting the handling of viral vectors, gene therapy-based vaccines and controlled materials.


RSSL’s team of cell specialists have a proven track record of developing innovative assays utilising continuous and primary cell lines, according to regulatory guidelines. With the ability to generate working cell banks for storage in on-site liquid nitrogen dewars, RSSL can aid in reducing cell-assay variability over time. 

Once validated in line with ICH guidelines or verified against pharmacopeial methods, RSSL’s experienced team can quickly transfer the confirmed method onto routine and/or stability testing schedules to fulfil your ongoing biopharmaceutical testing requirements. 

Cell Based assay services

 

  • Cell viability and proliferation assays 
  • Glucose uptake 
  • Lipid metabolism 
  • Cytotoxicity assays 
  • Antibody-dependent cell-mediated cytotoxicity 
  • Antibody-dependent cellular phagocytosis 
  • Bispecific T cell engager assays  
  • Custom TCR T cell activation assays 
  • Cytokine receptor engagement bioassay 
  • Intracellular cytokine expression assessment 
  • Cell surface membrane protein expression assessment  
  • Assessment of viral vector titre and transgene expression efficiency 

 

The diverse and in-depth expertise of RSSL’s cell specialists can be applied to collaboratively develop custom assays in line with your needs. 

 

With impressive laboratory capacity and competitive pricing models, get in touch to see how RSSL can support you from early-stage drug development and stability testing to approval and commercialisation.  

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