DSC and TGA can be applied in a broad range of ways to elucidate the number of polymorphs, hydrated forms, melting point, Tg, degradation behaviour, polymorphic conversion, recrystallisation and heat capacity of an API and excipients. DVS is used to study the response of material to changes in humidity, it is essential in understand physico-chemical behaviours such as stability and microbiological activity. Moisture induced phase changes can affect mechanical properties, induce chemical and biophysical interactions which can lead to changes in dose, yield and efficacy. XRD is a complimentary technique (see XRD offering).
The physical form of ingredients used in both food and pharmaceuticals can have a major impact on the desired properties for finished products. X-Ray Powder Diffraction (XRPD) is a powerful technique both on its own and in combination – DSC, TGA etc. XRPD can help to determine which available polymorph is most desired.
Particle size distribution (PSD) is a fundamental measurement in the product life cycle. The link between particle size and product performance are known to affect dissolution rate, absorption rates and content uniformity. The processability and stability of a formulation are all dependent on PSD.
During formulation of a product the flow and packing properties, tablet and capsule fill volumes, compression, dissolution and blend uniformity can all be affected by PSD. At RSSL we have a series of instruments that allow the measurement of PSD and particle shape/morphology. We are also highly experienced in method development and validation.
Our experts in rheology are able to apply their knowledge and analytical skills utilising our wide range of analytical techniques and formulation types. Emulsion or suspension formulations including, ointments, lotions and gels often need specific flow properties to enable them to remain stable, be dispensed appropriately, placed into suitable containers and applied correctly. Semisolid pharmaceuticals are intrinsically difficult to characterise rheologically as they combine liquid and solid properties within one system. Even simple fluids can affect processes such as heat and mass transfer and the rate of dissolution of a dosage form.
The structure and character of a formulation, drug product or medical device is vital for consumer acceptance and usage. Through a range of analytical techniques, we can help characterise the structure and mechanical properties of pharmaceutical products and medical devices throughout the product lifecycle from formulation, through stability and release testing. We can offer insights into how these affect functionalities for medical devices and pharmaceutical products.
SSA is dependent on the size of the particles, as well as on the structure and porosity of the material, these features are important for characterisation during screening for API’s and formulations. Understanding moisture adsorption/desorption of APIs and excipients is important during formulation processing, storage and for release.
Density is an important property of pharmaceutical compounds from powders to tablets. We provide a wide range of analytical techniques to determine density across various pharmaceutical compounds.
Using our Brookfield powder flow and FT4 Powder Rheometers we can characterise the flow of powder and granular excipients and active pharmaceutical ingredients to aid in manufacturing processes. This technique can be useful in troubleshooting caking and non-uniform flow through hoppers during processing. Our analysts will be able to provide direction on which analytical technique would be suitable for your needs.
Polymerase Chain Reaction (PCR) is a powerful molecular biology technique used to amplify and detect specific DNA sequences in a sample. By repeatedly cycling through a series of temperature changes, PCR can produce millions of copies of a target DNA segment, making it possible to identify and analyze genetic material with high sensitivity and precision. This technique is widely used in applications such as genetic testing, disease diagnostics, and forensic analysis, providing critical insights into genetic information across various fields.
Next-Generation Sequencing (NGS) is an advanced technology that enables the rapid sequencing of entire genomes or targeted regions of DNA and RNA. This method allows for high-throughput analysis, producing vast amounts of genetic data in a single run, which can be used for applications such as genomics research, personalized medicine, and mutation detection. NGS provides deep insights into genetic variation, making it a powerful tool for understanding complex biological processes and enabling precision medicine.
Third-Generation Sequencing is an advanced genomic technology that allows for the direct sequencing of single DNA or RNA molecules in real-time without the need for amplification. This technique offers longer read lengths compared to earlier methods, providing a more comprehensive view of complex regions of the genome, structural variations, and epigenetic modifications. Third-generation sequencing is particularly useful in applications like de novo genome assembly, studying large structural variations, and analyzing epigenetic changes, making it a powerful tool for cutting-edge genetic research and precision medicine.